We open on a long country road, where Trish (Gina Phillips) and Darry (Justin Long) are driving back home during Spring Break. As the two are driving down the road we learn that they are taking the long way home. Darry claims that the reason they are doing this is because Trish is trying to avoid getting home quick in order to postpone talking about her boyfriend from college. It is implied that Trish and her boyfriend are no longer together.
As they are driving they see an RV up ahead of them. Both try to figure out what the vanity plates message is a game the two like to play. As they pass the RV and begin driving further down the road, we see that behind them that the RV turns off the road quite suddenly. Then we see a beaten up van coming down the road behind Trish and Darry, unbeknownst to them.
The van approaches them quite quickly and tail gates them, honking the horn insistently. Trish yells at Darry to let him pass and Darry keeps swerving on the road. Finally, Darry moves over to the oncoming traffic lane and lets the van pass.
As the van passes, we see the license plates says, BEATNGU. Trish mentions that the encounter with the truck reminded her of Kenny and Darla. It was said that Kenny and Darla were drunk driving and that their bodies were never recovered only the vehicle was found. Darry disagrees and says that they just werent able to find her, Darlas, head or Kenny. Darry chalks it up to a generational cautionary tale of drinking and driving.
Despite this, Trish is still spooked and claims that she had always heard it was true that Kenny and Darla attended Wheaton Valley High and were part of the class of 78. Trish then tells Darry that when she first heard the story she thought she would die on that highway. The two then start bickering over whether or not Darry will get the point for the vanity plate on the van, claiming it read as beating you, since he didnt call it right when he saw the plate.
The two stop on the side of the road to urinate, Trish asks her brother if he had talked to their mother. He claims that he only told her that he would be home for break. Trish asks how her mother sounded, particularly if she sounded weird. As Trish gets back in the car she notices that Darry has a bag full of laundry for their mother to do. Trish then claims that something is wrong with their mother, which Darry denies. Trish says that he is unable to notice anything beyond his own existence and insists that their mother isnt happy.
At that point, Darry notices the beaten up van that tailgated them from before. It is by an old run-down church. As they slowly pass the van, we see that the driver is a guy with his face covered, wearing a hat and a dark trench coat. Both notice that he is dumping something wrapped in a bloody sheet down a pipe. On the drivers second trip to the pipe he notices the two watching him. The two begin asking each other what he was doing with the bloody sheets wrapped with rope.
Trish tells Darry to get them out of there, while Darry tells her to grab his cell phone in his gym bag. She finds the cell phone and notices that the van is now pulling out from the church and begins to follow them. Trish tries to use the phone but sees that his battery is low and despite the fact that Darry has a power plug for it, her lighter doesnt work.
The van is now catching up to their car at unnatural speed. As he catches up to them he smashes into the back of their car several times, finally running them off the road and into a field. The van continues on down the road. After Darry fixes the trunk of Trishs car, he stops and says that they need to go back. They both know that it was a person in the sheet and Darry wants to go back and check that the person isnt still alive. Trish doesnt want to and would rather get to a phone and call the cops.
Darry argues that they are too far away from a phone to be able to save the person if they are still alive. He finally convinces her by asking if it were her back there. They head back to the church, which is surrounded by crows. Upon approaching the pipe, which smells terrible, Darry claims to have heard something down there and he shines a light down there. So he climbs into the pipe, asking Trish to hold onto his feet. As he is shining the light down in the pipe he claims to see something, which happens to be rats.
Trish and Darry start screaming and in the commotion Trish lets go of Darry, leading Darry to fall down the pipe. While Darry is down there he notices the bloody sheet that the creepy guy threw down the pipe. He kicks it to see if the person is alive, and when it doesnt move he turns to yell up to Trish, when all of a sudden the person in the sheet grabs his leg. The person in the sheet starts to thrash around and Darry uncovers his face to find it is a boy not much older than him.
His face is blue and he starts pointing to his stomach. When Darry rips open the sheet he sees that the boys stomach has been opened up and sewn back together. The boy in the sheets starts to mumble something inaudibly and when Darry leans in to hear him better, the boy dies. Darry then goes back to the opening of the pipe and tells Trish that she needs to go back to the road and get help by flagging someone down.
Darry claims that he is going to find a way out. Before Trish can leave he tells her that if she sees the old van that she needs to run back to the pipe and let him know. Darry then heads further into the basement and sees more bodies wrapped in sheets. He then sees that there is an opening into a room. As he inspects the room he finds a bunch of weird instruments and bottles.
As he is looking he notices that his show is untied and upon bending down to tie it his flashlight shines on the wall behind him showing a collection of naked human bodies, all arranged weirdly onto the wall. All of a sudden, something drips onto Darrys shoe. He shines his flashlight up to the ceiling and sees hundreds of bodies all over the walls. Trish is out on the road watching for cars, which there seem to be none approaching from either direction.
While she is out there we cut back to Darry down in the basement where he has found an opening leading out of the basement. As he approaches it he notices two bodies sewn together in the corner. The womans sewn on head is placed on the guys shoulders, their arms sewn together leading to their hands intertwined with one anothers. Darry notices a class ring on the guys finger which says Wheaton Valley High.
Back on the road, Trish is facing oncoming traffic in the left lane. While she is facing this way, behind her we see headlights approaching in the distance. Finally, Trish looks behind her and sees what looks to be a beaten up van coming towards her. She hops into her car and tries to start the car, but it seems as though the cars clutch is stuck in gear. As the vehicle comes closer we see that it wasnt the beaten up van but a beaten up truck with hay in the back.
As she relaxes from having scared herself thinking it was the creepy guy, her brother, Darry pops up by her window looking completely in shock. The two begin heading down the road again, Trish trying to get Darry to say something. Trish notices that they are low on gas and claims that they need to stop as she passes a sign that reads they are entering Pertwilla. At that point, Darry speaks up mentioning that the tales about Kenny and Darla were true and that she did lose her head.
Trish pulls into a diner with a gas pump. As they get out of the car they are discussing that they need to call the cops and Darry needs to tell them what he found. At that point, we see the beaten up van pass by the diner, heading back to the run-down church. Both run into the diner, asking for a phone to call the cops. Everyone in the diner looks at them puzzled. Finally, the waitress goes to call the cops.
Trish turns to her brother, trying to snap him out of his frightened state when the payphone in the diner rings. Trish picks it up and a woman asks if they have seen the cats yet. The woman on the phone explains that she had seen her and Darry with lots of cats. Trish, confused, asks how she knows Darry. At this point, Darry takes the phone and starts asking the woman who she is.
The woman continues on proving that she knows who they are by describing Darrys torn shirt, bloody hand, and rose tattoo on his stomach. She tells them that they have found its house of pain. She explains it to be a hungry thing that will not stop coming after them or anyone else it wants. She proclaims that once it has the scent of something it likes, it cant stop. She says that she saw the awful truck/van, too, with the weird license plate.
Darry asks, Beating you? She tells him no, and to think about it. Then she tells him to listen to something. On her speaker she has playing Jeepers Creepers (Jeepers Creepers, where'd you get those peepers/Jeepers Creepers, where'd you get those eyes. She tells Darry that when he hears that song to run because it means something terrible for him. Darry ends up hanging up on her.